Yorkie Poos are generally healthy (as most mixed breeds are), but they can suffer their share of health problems, such as patellar luxation (a dislocated kneecap), liver shunts, epilepsy, Legg-Calve-Perthes Disease (a degeneration of the femur bone), hypothyroidism, and atopic dermatitis.
Obesity can also be an issue. Keeping a Yorkipoo at a healthy weight will extend his life.